Antitumoractivity相关论文
Novel 2,4-Diarylaminopyrimidine Derivatives Containing Pyridine Moiety:Design,Synthesis,Crystal Stru
A series of 2,4-diarylaminopyrimidine derivatives containing pyridine structure were designed and synthesized.The crysta......
Combined nanosuspensions from two natural active ingredients for cancer therapy with reduced side ef
Tumor drug resistance and systemic side effects of chemotherapeutic drugs are the main reasons for the failure of cancer......
替加氟是一种转化为5-氟尿嘧啶的口服化疗前药,主要通过抑制胸苷酸合酶激活并杀死肿瘤细胞.本研究通过取代、水解、缩合合成了20种......
Polyoxometalates (POMs) are a class of well-defined transition metal-oxide nanoclusters and have potential applications ......
Synthesis,characterization and antitumor activities in vitro of a coordination polymer based on Pyri
Since the antitumor effect of certain metal ions and complexes reported,antitumor metal complexes have been the focus of......
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Synthesis and evaluation of phthalamide derivatives containing aliphatic and aromatic amine as poten
Objective The great importance of chemotherapy motivated researchers to discover potent novel antitumor drugs.Various gr......
The Anti-tumor effect and the mechanism of A Novel Herbal decoction on A549 human lung cancer cell l
Objective Lung cancer is still the first cause of tumor-related death in both developing and developed countries.As a su......
Histone deacetylases(HDACs)were reported as targets of anticancer drugs.It can silence tumor suppressor genes by the alt......
Synthesis of N-(4-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3-fluorophenyl)picolinamide derivatives as c-
c-Met is a proto-oncogene that encode a protien known as hepatocyte growth factor receptor(HGFR)[1].Inappropriate activi......
School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou,450001 Piperlongumine(PL,Figure 1),a natural occurring ......
[Pt(IQ)(DMSO)Cl](1)with 5,7-diiodo-8-hydroxyquinoline(H-IQ),were synthesized and fully characterized.1 is more selective......
1,4-Naphthoquinones(1,4-NQs)are a class of aromatic motifs that are widely present among natural products and synthetic ......
Protein kinase CK2 is a multifunctional serine/threonine kinase that involved in a broad range of physiological events,a......
Synergistic and attenuated effect of active protein P23 in combination treatment with docetaxel plus
Aim Platinum based combination regimens are firstline treatment option in treatment of NSCLC but the clinical utility ha......
Design,synthesis and biological evaluations of isoniazid/pyrazinamide/ethambutol-quinoline conjugate
A series of novel isoniazid/pyrazinamide/ethambutol-quinoline conjugates based on the commonality in the structures of a......
Redox and pH dual responsive poly (amidoamine)dendrimer-poly (ethylene glycol) conjugates for intrac
To solve the contradiction between long circulation time and effective intracellular drug release, redox and pH-responsi......
Geldanamycin (GA),a benzoquinone ansamycin,was reported as the first heat shock protein 90 (Hsp90) inhibitor.GA binds to......
Preparation,characterization and in vitro antitumor activity of curcumin-loaded mPEG-PLA Nanoparticl
OBJECTIVE To prepare Curcumin-loaded methoxy polyethylene glycol-polylactic acid (mPEG-PLA) nanoparticles (CUR-mPEG-PLA-......
Redox-sensitive polymer-drug conjugate of doxorubicin conjugated stearic acid-g-chitosan oligosaccha
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Anti-tumor effect of the polysaccharides from cultivated Dendrobium huoshanense stems on lung carcin
Cancer is one of the major public health problems globally which remains a disease of high morbidity and mortality.At pr......
The Saponin Components of T.tschonoskii Produced Anti-gastric Cancer Effects via Acting on Ras Signa
Aim: To identify the main antitumer compounds of T.tschonoskii and explore the underlying mechanism.Methods: The antitum......
Hsp90 is a molecular chaperone responsible for facilitating maturation of client proteins include oncogenic tyrosine kin......
Designing perfectly amphiphilic a-helical peptides with enhanced cell specificity,endotoxin neutrali
The emergence of antibiotic resistance has increased demands for new antimicrobials with novel mechanisms of action.Anti......
Tumor has become a serious threat to human health and life.Thus,it is of great significance to search for low toxic and ......
Nitrido-osmium(Ⅵ)bidentate pyrazolate complexes induces apoptosis in HepG2 cells via mitochondrial p
Osmium complexes are potential anticancer candidates which act through different mechanisms from cisplatin-based chemoth......
Indoleamine 2,3-dioxygenase 1(IDO1)and tryptophan 2,3-dioxygenase(TDO)are constitutively overexpressed in many types of ......
Fluticasone propionate,a new type of glucocorticoid developed by Glaxosmithkline in the United Kingdom,has strong effica......
Synthesis,crystal structure and biological activity of two Mn complexes with 4-acyl pyrazolone deriv
A great many Schiff base complexes with transition metals have been confirmed possessing biological and pharmaceutical a......
Design,Synthesis,and Anticancer Effect Studies of Iridium(Ⅲ)Polypyridyl Complexes against HeLa Cells
An iridium(Ⅲ)complex([Ir(PTTP)2(ppy)](PF6)(Ir-1)were synthesized and characterized.The cytotoxicity of Ir-1 against can......
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Recently,PtⅣ prodrugs have attracted much attention as the next generation of platinum-based antineoplastic drug candid......
Anti-tumor, anti-oxidant activity, and isolation of the anti-tumor active compounds from Voacanga Af
Voacanga africana Stapf.(Apocynaceae),a tree plant occuning in all of West Africa and as far as the Congo and even Tanza......
IN-PP21:Syntheses, crystal structure, Antimicrobial and antitumor activities of Ag(I) complex from 2
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Malignant tumor is a life-threatening disease worldwide and the number of tumor patients is still increasing year by yea......
Evodiamine-inspired Dual Histone Deacetylase 1(HDAC1)and Topoisomerase 2(Top 2)Inhibitors with Poten
A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages ......
Phosphoinositide 3-kinase(PI3K)is an attractive target to potentially treat a range of disease stales as illustrated by ......
New Biomaterials Based On Silver Nanoparticles And Polyphenols From Viburnum Opulus Fruits With Pote
The biological synthesis of silver nanoparticles (AgNPs) using plants or fruits extracts plays an important role in the ......
Discovery of New Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activi
Histone deacetylases (HDACs) are a family of enzymes that catalyze the deacetylation of lysine side chains in chromatin,......
Platinum(Ⅱ) Complexes Containing Reduced Amino Acid Ester Schiff-bases: Synthesis,Characterization a
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Cholic acid,a kind of steroid compound synthesized in animals liver,is an essential substance of enterohepatic circulati......
Synthesize a series of dibenzodiazepine derivatives by exploring the method for the construction of the skeleton of dibe......
DNA Binding Properties and Biological Evaluation of Dihydropyrimidinones Derivatives as Potential An
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DNA Binding and Antitumor Activity of a New Fluorescent Probe Eu(Ⅲ)-Complex Containing 4-Methyl-Coum
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Efficacy and safety of icotinib in Chinese patients with advanced non-small cell lung cancer after f
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DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro a
Fibroblast growth factor receptor (FGFR) is a promising anticancer target.Currently,most FGFR inhibitors lack sufficient......
